After rising through the ranks of her male-dominated profession, idealistic FBI agent Kate Macer (Emily Blunt) receives a top assignment. Recruited by mysterious government official Matt Graver (Josh Brolin), Kate joins a task force for the escalating war against drugs. Led by the intense and shadowy Alejandro (Benicio Del Toro), the team travels back-and-forth across the U.S.-Mexican border, using one cartel boss (Bernardo Saracino) to flush out a bigger one (Julio Cesar Cedillo).
1971. Larry Sportello – better known as Doc – is a pot head hippie private eye based in Gordita Beach in southern California. He is approached by ex-lover Shasta Fay Hempworth, who believes her current boyfriend, married land developer Mickey Wolfmann, is the target of an abduction attempt by his wife and her lover. In helping Shasta, Doc not only goes on a search for Wolfmann, but others who go missing, including Shasta, and one who is assumed to be murdered. Along the way, Doc gets involved with a crazy cast of characters and a wide array of issues from politics, cults, prostitution, the drug trade and dentistry, much of it surrounding the mysterious “Golden Fang”. Along for most of the ride is LAPD detective Christian Bjornsen – Bigfoot to most who know him – who is straight-laced on the outside, but who has a dark underside, which is supported by a hefty therapy bill.
Marv is unconscious on a highway surrounded by corpses. When he awakes, he has amnesia and tries to recall his last steps from the Kadie’s saloon on the Saturday night. He recalls that he found four playboys burning a homeless man alive and defended the poor man. Marv hunts them down and kills the group. The cocky gambler Johnny hits jackpot in slot machines in the Kadie’s saloon and invites the waitress Marcie to go with him to play poker game against the powerful Senator Roark. He wins the game and suffers the consequence of his arrogance. The private detective Dwight McCarthy is contacted by his former lover Ava Lord that asks to meet him at the Kadie’s saloon. Ava asks him for forgiveness for leaving him to marry the wealthy Damian Lord. However her strong chauffeur Manute takes her home. Dwight snoops around Ava’s house but is found and beaten by Manute and the bodyguards. When he returns home, Ava is waiting for him naked in the bed and seduces him again. Then she tells that Damian and Manute torture her and soon she will be killed. Once again Manute takes Ava with him and hits Dwight that invites Marv to help him to rescue Ava. Damian denies the accusation but Dwight beats him to death while Marv tear Manute’s eye out. But soon Dwight finds that he was lured by Ava that shoots him. Marv rescues Dwight and takes him to the Old Town where Dwight finds his former lover Gail that helps him to recover while Dwight plots revenge against Ava.